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  • Title: Initiation of reticular and spider veins, incompetent perforantes and varicose veins in the saphenous vein network of the rat.
    Author: Patai BB, Dornyei G, Tokes AM, Hetthessy JR, Fees A, Nadasy GL.
    Journal: Sci Rep; 2020 Sep 21; 10(1):15381. PubMed ID: 32958828.
    Abstract:
    In an attempt to induce experimental varicosity, reverse perforant vein development was initiated in the rat leg by applying a chronic (14 and 32 weeks) partial stricture on the main branch of the deep femoral vein. At surfacing of the incompetent perforantes, typical reticular vein plaques and spider veins were identified by video-microscopy and quantitative histology. Deep vein blood was channeled by them into the saphenous vein system, the extra flow deforming these vessels, causing local dilations and broken course, even undulations of larger branches.
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