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Title: [Manual acupuncture stimulation of acupoints at the same and adjacent spinal segments promotes uterine contractility].
Author: Tang YW, Cui X, Liu K, Li XX, Han S, Zhao J, Wang SY, Chen YY, Gao XY, Zhu B.
Journal: Zhen Ci Yan Jiu; 2020 Sep 25; 45(9):708-13. PubMed ID: 32959552.
Abstract:
OBJECTIVE: To investigate the effect of manual acupuncture stimulation of acupoints at different spinal nerve segments on uterine motility and the complicated adrenergic and cholinergic receptors. METHODS: Eighteen adult non-pregnant SD rats were used in the present study. The contractive activities of the uterus were measured by using a pressure transducer which was connected to an inserted water-filled balloon in the uterus via a PE tube at one end and an amplifier at the other end. Manual acupuncture needle was applied to "Zigong"(EX-CA1),"Huiyin" (CV1), "Xuehai "(SP10) and "Taichong "(LR3) acupoints located at the same or adjacent spinal nerve segments of the uterus, and to "Neiguan" (PC6) situated at the distant spinal nerve segment at about 2 Hz for 1 min, followed by observing changes of the uterine contractility. After acupuncture, α-adrenoceptor antagonist phentolamine (0.5 mg/kg, n=9) or cholinergic muscarinic (M) receptor antagonist atropine (0.5 mg/kg，n=9) was given to the rats of different acupoints respectively through tail vein, followed by observing changes of the uterine automatic systolic pressure difference (value of systolic pressure peak minuses the trough value) and frequency after manual acupuncture stimulation as well as after blocking the activities of α-adrenoceptors and M receptors, separately. RESULTS: After acupuncture stimulation of EX-CA1, CV1, SP10 and LR3, but not PC6, the systolic pressure difference and frequency of the uterus were signi-ficantly increased (P<0.05,P<0.001, P<0.01). Following intravenous injection of phentolamine, both the systolic pressure difference and frequency had no marked changes after acupuncture at the 5 acupoints (P>0.05). After intravenous injection of atropine, the uterine systolic pressure difference and frequency were markedly decreased compared with the basic values before acupuncture stimulation (P<0.001), but had no obvious changes after acupuncture at the 5 acupoints at both the same and distant spinal segments to the uterus (P>0.05). CONCLUSION: Manual acupuncture stimulation of acupoints at the same and adjacent spinal segments can promote the contractility of uterus in normal rats, which is realized by activating both α-adrenoceptor and cholinergic M receptors. 目的：观察针刺不同节段穴位(部位)对SD大鼠子宫运动的调节效应及自主神经的相关联系。方法：健康成年未孕SD大鼠18只，采用球囊置入法记录未孕状态时子宫的自发性收缩活动；随后分别在与支配子宫相同/近节段穴位“子宫”“会阴”“血海”“太冲”及异节段穴位“内关”给予手针干预(刺激频率2次/s，持续1 min)，每次干预间隔5 min，比较针刺不同节段穴位对子宫运动的影响；分别经尾静脉注射肾上腺素能α受体阻断剂酚妥拉明(0.5 mg/kg)和胆碱能M受体阻断剂阿托品(0.5 mg/kg)，观察子宫运动及针刺上述穴位调节效应的变化。结果：生理条件下，针刺与子宫同/近节段穴位“子宫”“会阴”“血海”“太冲”后子宫的收缩压力差和收缩频率较基础值显著增加(P<0.05，P<0.001，P<0.01)，而针刺异节段“内关”与基础值比较差异无统计学意义(P>0.05)。与基础值比较，尾静脉注射阿托品后大鼠子宫的收缩压力差和收缩频率显著降低(P<0.001)，而尾静脉注射酚妥拉明后差异无统计学意义(P>0.05)。与注射阿托品或酚妥拉明后比较，针刺与子宫相同节段和异节段的上述穴位后子宫收缩压力差和收缩频率差异均无统计学意义(P>0.05)。结论：副交感胆碱能M受体与子宫节律性收缩运动联系密切，针刺与支配子宫同/近神经节段的穴位可显著促进子宫的收缩运动，这种促进效应可能与肾上腺素α受体和胆碱能M受体激活相关。.

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