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  • Title: PHA dose dependent defect in lymphocyte stimulation and E-rosette-forming cells in untreated Hodgkin's disease.
    Author: Land JM, Litwin J, Bigel P, Oberling F, Mayer S.
    Journal: Acta Haematol Pol; 1977; 8(2):131-4. PubMed ID: 329629.
    Abstract:
    14 untreated patients with Hodgkin's disease were tested for lymphocte reactivity in vitro to optimal and suboptimal doses of PHA. A PHA dose-dependent defect in lymphocyte stimulation was demonstrated in patients when compared with a group of normal individuals. No correlation between the in vitro defect and decreased absolute number of E-rosette-forming cells (T-lymphocytes) in peripheral blood was found.
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