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  • Title: [Allogeneic bone marrow transplantation in acute myeloid leukemia (AML): results in 14 patients].
    Author: Kos M, Hinterberger W, Gadner H, Haas O, Kalhs P, Panzer S, Geissler K, Schwarzinger I, Hinterberger-Fischer M, Neumann E.
    Journal: Wien Klin Wochenschr; 1987 Apr 03; 99(7):217-22. PubMed ID: 3296468.
    Abstract:
    Between February 1982 and August 1986 14 patients with AML (median age 24 years, range 10-41) underwent allogeneic bone marrow transplantation. 9 patients were grafted in first complete remission, 4 in first relapse, 1 in second relapse and 1 patient with refractory AML. Conditioning consisted of cyclophosphamide (120 mg/kg) and total body irradiation (1000 rad). The patients received methotrexate (n = 12) or methotrexate and cyclosporine (n = 2) for prevention of graft versus host disease. Of the 14 patients, 7 are alive, 7 patients died. Causes of death were recurrence of leukaemia (n = 2), veno occlusive disease of the liver (n = 1), CMV-pneumonitis (n = 1), septicaemia (1), cerebral haemorrhage (1), acute graft versus host disease of the gut (1), necrotizing encephalopathy (n = 1). 7 patients are alive between 124 and 1784 days (median 671) in continuous complete remission. All patients but 1 have a Karnofsky-index of more than 80%.
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