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  • Title: T-cell prolymphocytic leukemia with an unusual phenotype CD4+ CD8+.
    Author: Kluin-Nelemans HC, Gmelig-Meyling FH, Kootte AM, den Ottolander GJ, Termijtelen A, Kluin PM, Beverstock GC, Brand A.
    Journal: Cancer; 1987 Aug 15; 60(4):794-803. PubMed ID: 3297298.
    Abstract:
    A patient with T-cell prolymphocytic leukemia (T-PLL) is described. The outcome was poor, with death 8 months after diagnosis, despite several therapeutic interventions. The cells carried both CD4 and CD8 epitopes, but other thymocytic markers were absent. The spleen showed infiltration of CD4+ CD8+ prolymphocytes in the red pulp and in T-cell-dependent areas of the white pulp. Immunologic function studies revealed proliferation after stimulation with mitogens and even several antigens. However, in the mixed lymphocyte culture the T-PLL cells did not proliferate. Cytotoxic T-cells could not be induced. In T-non-T recombination experiments neither helper nor suppressor cell function was found for pokeweed mitogen-dependent plasmablast generation of normal B-cells. Cytogenetically, many abnormalities were found. Among them, 14q+; absence of chromosomes 8, 11, and 22; and the presence of large marker chromosomes and fragments.
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