These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Central odontogenic fibroma: an international multicentric study of 62 cases.
    Author: Roza ALOC, Sousa EM, Leite AA, Amaral-Silva GK, Morais TML, Wagner VP, Schuch LF, Vasconcelos ACU, de Arruda JAA, Mesquita RA, Fonseca FP, Abrahão AC, Agostini M, de Andrade BAB, da Silveira EJD, Martínez-Flores R, Rondanelli BM, Alberdi-Navarro J, Robinson L, Marin C, Assunção Júnior JNR, Valiati R, Fregnani ER, Santos-Silva AR, Lopes MA, Hunter KD, Khurram SA, Speight PM, Mosqueda-Taylor A, van Heerden WFP, Carlos R, Wright JM, de Almeida OP, Romañach MJ, Vargas PA.
    Journal: Oral Surg Oral Med Oral Pathol Oral Radiol; 2021 May; 131(5):549-557. PubMed ID: 32988809.
    Abstract:
    OBJECTIVE: The aim of this study was to report the clinicopathologic features of 62 cases of central odontogenic fibroma (COdF). STUDY DESIGN: Clinical and radiographic data were collected from the records of 13 oral pathology laboratories. All cases were microscopically reviewed, considering the current World Health Organization classification of tumors and were classified according to histopathologic features. RESULTS: There were 43 females and 19 males (average age 33.9 years; range 8-63 years). Clinically, COdF lesions appeared as asymptomatic swellings, occurring similarly in the maxilla (n = 33) and the mandible (n = 29); 9 cases exhibited palatal depression. Imaging revealed well-defined, interradicular unilocular (n = 27), and multilocular (n = 12) radiolucencies, with displacement of contiguous teeth (55%) and root resorption (46.4%). Microscopically, classic features of epithelial-rich (n = 33), amyloid (n = 10), associated giant cell lesion (n = 7), ossifying (n = 6), epithelial-poor (n = 3), and granular cell (n = 3) variants were seen. Langerhans cells were highlighted by CD1a staining in 17 cases. Most patients underwent conservative surgical treatments, with 1 patient experiencing recurrence. CONCLUSIONS: To the best of our knowledge, this study represents the largest clinicopathologic study of COdF. Most cases appeared as locally aggressive lesions located in tooth-bearing areas in middle-aged women. Inactive-appearing odontogenic epithelium is usually observed within a fibrous/fibromyxoid stroma, occasionally exhibiting amyloid deposits, multinucleated giant cells, or granular cells.
    [Abstract] [Full Text] [Related] [New Search]