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  • Title: [Results of a multicenter study of an amoxicillin-clavulanic acid combination in sinusitis in children and adults].
    Author: Le Clech G, Bourdinière J.
    Journal: Ann Otolaryngol Chir Cervicofac; 1987; 104(2):147-50. PubMed ID: 3300504.
    Abstract:
    Efficacy and safety of Augmentin were evaluated in 79 patients, 64 adults and 15 children, treated for sinusitis during a multicentric hospital trial. Pre-treatment meatal pus samples were examined for bacteriology: 37 of 39 strains (95%) isolated from adults were sensitive to Augmentin, and two beta-lactamase producing Haemophilus strains sensitive to Augmentin were isolated from the children. Adult dosage was usually 2 g per day as two divided doses over 8 to 10 days. Recovery was obtained at end of treatment in 92% of cases, side effects being reported in 56 patients, including 8 with benign digestive disorders. Usual dosage in children was 25 to 50 mg/kg/d over 8 to 10 days and treatment was effective in 13 cases. One child developed a skin rash, and there was no report of digestive disturbance.
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