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  • Title: Terpenes isolated from Polyalthia simiarum and their cytotoxic activities.
    Author: Duan XY, Guo KY, Lv DJ, Mei RQ, Zhang MD.
    Journal: Fitoterapia; 2020 Nov; 147():104734. PubMed ID: 33007399.
    Abstract:
    Two new C31 triterpenes, polysimiaric acid A (1) and B (2) as well as one new clerodane diterpenoid, 16,16-dimethoxy-cleroda-3,13Z-dien-15-oic acid (3), together with six known compounds were isolated from Polyalthia simiarum. Their structures were determined by analysis of 1D and 2D NMR data. Three new compounds were tested for their cytotoxicity against five human tumour cell lines. Compound 3 showed cytotoxic activities against SMMC-7721 with the IC50 value of 22.43 μM.
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