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Title: A target-induced amperometic aptasensor for sensitive zearalenone detection by CS@AB-MWCNTs nanocomposite as enhancers. Author: Mu Z, Ma L, Wang J, Zhou J, Yuan Y, Bai L. Journal: Food Chem; 2021 Mar 15; 340():128128. PubMed ID: 33010646. Abstract: In this research, a novel signal-on aptasensor for highly sensitive detection of zearalenone (ZEN) was reported based on target-induced amplification strategy. Specifically, chitosan functionalized acetylene black and multi-walled carbon nanotubes (CS@AB-MWCNTs) nanocomposite with large specific surface area and excellent conductivity was synthesized and served as the sensing platform. In addition, carboxylated graphene oxide-labeled ZEN binding aptamer (CGO-ZBA) would specifically recognized with ZEN to detach from the electrode, allowing the electrochemical signal of [Fe(CN)6]3-/4- increased more obviously. Under the optimal conditions, the proposed aptasensor exhibited exceptional detection performances for ZEN with a linear range from 10 fg mL-1 to 1 ng mL-1 and a low limit of detection of 3.64 fg mL-1. Given its great sensitivity, excellent selectivity, satisfactory stability and reproducibility, this method would provide a promising application for ZEN and other biomolecules by replacing the corresponding nucleicacidsequences.[Abstract] [Full Text] [Related] [New Search]