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  • Title: Genetic alphabet expansion technology by creating unnatural base pairs.
    Author: Kimoto M, Hirao I.
    Journal: Chem Soc Rev; 2020 Nov 07; 49(21):7602-7626. PubMed ID: 33015699.
    Abstract:
    Recent advancements in the creation of artificial extra base pairs (unnatural base pairs, UBPs) are opening the door to a new research area, xenobiology, and genetic alphabet expansion technologies. UBPs that function as third base pairs in replication, transcription, and/or translation enable the site-specific incorporation of novel components into DNA, RNA, and proteins. Here, we describe the UBPs developed by three research teams and their application in PCR-based diagnostics, high-affinity DNA aptamer generation, site-specific labeling of RNAs, semi-synthetic organism creation, and unnatural-amino-acid-containing protein synthesis.
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