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  • Title: Role of class I and class II HLA antigens in cadaveric renal transplantation.
    Author: Sengar DP, Couture RA, Raman S, Jindal SL, Lazarovits AI.
    Journal: Transplant Proc; 1987 Aug; 19(4):3422-5. PubMed ID: 3303509.
    Abstract:
    HLA matching at MT and DQ appears to be an important predictor of allograft survival. Allografts with no MM at MT and DQ have a good outcome while a known MM at MT and DQ appears to be associated with poor allograft outcome. Thus, our priority should be to avoid an MM for these broad-reacting specificities and then to minimize incompatibilities at DR and HLA-B. Furthermore, our data indicate that allografts with MM at DQ and two MMs at HLA-B appear to be at a higher risk. Perhaps these latter transplants should not be performed with conventional immunosuppressive therapy.
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