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  • Title: [Problematic aspects of placebo-controlled double-blind studies with highly effective drugs such as etretinate].
    Author: Schwanitz HJ.
    Journal: Z Hautkr; 1987 May 15; 62(10):785-6, 791. PubMed ID: 3303711.
    Abstract:
    Highly potent drugs should be studied by means of double placebo experiments rather than by semi-blind trials. In semi-blind trials, possible side effects induced by the placebo might not be sufficiently registered, and those induced by the verum cannot be adequately evaluated.
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