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  • Title: [Effect of benzydamine on release of prostaglandin E2 and prostacyclin from rabbit gastric mucosa cells].
    Author: Hell M, Bauer AC, Sewing KF.
    Journal: Arzneimittelforschung; 1987 May; 37(5A):624-5. PubMed ID: 3304303.
    Abstract:
    The effect of the antiinflammatory drug benzydamine (Tantum) on prostaglandin E2 (PGE2) release from rabbit gastric mucosal cells was investigated. Up to 1 mmol/l benzydamine had no significant effect on PGE2 and prostacyclin (PGI2) formation and release. The lack of interference with gastric mucosal prostaglandin synthesis might explain the non-ulcerogenicity of this compound compared to other non-steroidal antiinflammatory drugs (e.g. indomethacin).
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