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  • Title: [Three-dimensional imaging study on the anatomical morphology of trabecular bone of the condyle based on the distribution of volume of interests].
    Author: Li F, Xu XL, Rong QG, Wang JW, Zhang JW, Zhou W, Guo CB.
    Journal: Zhonghua Kou Qiang Yi Xue Za Zhi; 2020 Oct 09; 55(10):765-771. PubMed ID: 33045789.
    Abstract:
    Objective: To analyze the anatomical morphological characteristics of the trabecular bone of human mandibular condyle by observing the distribution of volume of interests (VOI). Methods: The micro-CT images of a right condyle specimen of a 61-year-old adult male was analyzed in this study. The cylindrical VOI with both diameter and height of 2 mm were arranged, according to a certain pattern, as many as possible at various levels within the trabecular bone of the condyle. Each VOI had no intersection area. The selected VOI were divided into 5 parts: medial part, middle part, lateral part, anterior part and posterior part, with 6 layers from top to bottom. And the distribution of the overall anatomical morphological characteristics of three-dimensional (3D) images of the trabecular bone of the condyle was analyzed by using seven morphological parameters of each VOI, i.e. bone mineral density (BMD), bone volume/total volume (BV/TV), bone surface area/bone volume (BS/BV), trabecular thickness (Tb.Th), trabecular bone number (Tb.N), trabecular spacing (Tb.Sp) and trabecular bone pattern factor (Tb.Pf). Results: In the present study, totally 34 VOI were selected from the condyle specimen.The morphological distribution of the VOI was uneven in the 3D structure of the trabecular bone of the human condyle. BMD, BV/TV, Tb.N and Tb.Th were much higher at the middle part, while showed the smallest at the medial part. The anterior part demonstrated much higher parameters than the posterior part at the first, second, fifth and sixth layers, respectively, however, the posterior part showed much higher parameters than the anterior part at the third and fourth layers, respectively. The BMD was much higher at the first [(332.66±97.11) mg/cm3] and sixth [(255.79±45.68) mg/cm3] layers, while the lowest at the second layer [(255.79±41.06) mg/cm3]. The BV/TV and Tb.N were much higher at the first layer, with the lowest at the fifth layer. The Tb.Th at the first layer [(0.11±0.03) mm] was much higher than the others, which were similarly lower. The BS/BV, Tb.Sp and Tb.Pf were lower at the first layer and much higher at the medial and lateral parts, while were lower at the middle and anterior parts. The posterior part demonstrated much higher BS/BV, Tb.Sp and Tb.Pf than the anterior part at the first, fifth and sixth layers, respectively. However, the anterior part showed much higher scores than the posterior part at the third and fourth layers, respectively. The ANOVA results showed that the 7 morphological parameters of VOI were not statistically significant amongst the 6 layers (P>0.05). However, the 6 out of the 7 parameters, i.e. BV/TV, BS/BV, Tb.Th, Tb.N, Tb.Sp and Tb.Pf, were statistically significant amongst the five parts (P<0.05), while the only parameter of BMD was not statistically significant (P>0.05). Conclusions: The anatomical distribution characteristics of the trabecular bone of condyle were analyzed by using 3D imaging measurement based on the VOI. The results showed uneven distributions and indicated that the method of dividing the trabecular bone of mandibular condyle into VOI sets, which accorded with its specific anatomical characteristics, was feasible for further reference. 目的： 观察髁突骨小梁结构单元感兴趣区（volume of interest，VOI）的分布特点，分析髁突骨小梁的三维影像解剖形态特征。 方法： 对北京大学医学部遗体捐献的1例61岁男性尸体右侧髁突标本的micro-CT影像进行分析。在髁突骨小梁范围内不同层面按规律尽可能多地排列直径2 mm、高度2 mm的圆柱体VOI单元，且各VOI单元无交叉区域。将选取的VOI单元划分为内、中、外、前、后共5个区，从上到下共6层，通过分析每个VOI单元的骨矿物质密度（bone mineral density，BMD）、骨体积分数（bone volume/total volume，BV/TV）、骨比表面积（bone surface area/bone volume，BS/BV）、骨小梁厚度（trabecular thickness，Tb.Th）、骨小梁数量（trabecular bone number，Tb.N）、骨小梁分离度（trabecular spacing，Tb.Sp）以及骨小梁模式因子（trabecular bone pattern factor，Tb.Pf）等7个形态学参数，获取髁突骨小梁整体三维影像解剖形态特征的分布情况。 结果： 本研究扫描的髁突标本共选取34个VOI单元，BMD、BV/TV、Tb.Th和Tb.N在中区均值较大，内区均值最小，在1、2、5、6层前区>后区，3、4层后区>前区；BMD在1层［（332.66±97.11） mg/cm3］和6层［（344.24±45.68） mg/cm3］较高，2层［（255.79±41.06） mg/cm3］最低；BV/TV和Tb.N在1层较高，5层最低；Tb.Th在1层［（0.11±0.03） mm］较高，其余层数值相近且较低。BS/BV、Tb.Sp和Tb.Pf在1层较低，总体上内区和外区较高，中区和前区较低，1、5、6层后区>前区，3、4层前区>后区。ANOVA分析显示，VOI单元的7个形态学参数在6层间差异均无统计学意义（P>0.05）；但在5个分区间BV/TV、BS/BV、Tb.Th、Tb.N、Tb.Sp和Tb.Pf差异均有统计学意义（P<0.05），BMD则差异无统计学意义（P>0.05）。 结论： 本研究基于VOI单元对髁突骨小梁进行划分，获得髁突骨小梁三维影像解剖特征分布数据，显示髁突骨小梁的三维影像解剖形态区域分布不均匀，该方法可进一步分析髁突骨小梁结构的三维影像解剖形态学等特征。.
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