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  • Title: Composition of polysaccharides and radiosensitizing activity of native and sulfated laminarans from the Tаuуа basicrassa Kloczc. et Krupn.
    Author: Zvyagintseva TN, Usoltseva RV, Shevchenko NM, Anastyuk SD, Isakov VV, Zvyagintsev NV, Krupnova TN, Zadorozhny PA, Ermakova SP.
    Journal: Carbohydr Polym; 2020 Dec 15; 250():116921. PubMed ID: 33049835.
    Abstract:
    Polysaccharide fractions of alginate, laminarans and fucoidans were obtained from the brown alga Tauya basicrassa. Yields of alginate and laminarans were large (19.7 % and 5.62 %, respectively), whereas the content of fucoidans (0.52 %) was not significant. Alginate and laminarans had typical structures for those substances. Fucoidans were low- and medium-sulfated heterogeneous polysaccharides. The fucoidan fraction 1TbF1 was sulfated fucogalactan containing a backbone from 1,6-linked residues of β-d-galactopyranose with branches at C3 and C4, terminal fucose and galactose residues and fragments from 1,3-; 1,4-; and 1,2-fucose residues. Sulfate groups were found at positions 2 and 4 of fucose, and positions 2, 3 and 4 of galactose residues. Laminaran 2TbL was subjected to a sulfation to obtain the derivative 2TbLS with partial sulfation (46 %) at C2, C4 and C6. It was shown that 2TbL and 2TbLS inhibited colony formation of sensitize-tested colon cancer cells HT-29 and HCT-116 to X-ray radiation.
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