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  • Title: Trial of a cysteine proteinase inhibitor, EST, in experimental chloroquine myopathy in rats.
    Author: Sugita H, Higuchi I, Sano M, Ishiura S.
    Journal: Muscle Nerve; 1987; 10(6):516-23. PubMed ID: 3306368.
    Abstract:
    The administration of 50 mg/kg/day of chloroquine to rats for 8 weeks produced the chloroquine myopathy characterized by autophagic vacuole formation and increases in lysosomal enzymes, especially cathepsins B & L. Coadministration of 10 mg/kg/day of a potent cysteine proteinase inhibitor, EST, and chloroquine prevented the induction of the chloroquine myopathy. Rats already suffering from the chloroquine myopathy were treated with 10 mg/kg/day of EST together with chloroquine injections for 5 weeks and also recovered remarkably from the myopathy. Thus, EST may be beneficial for myopathies associated with autophagic vacuoles.
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