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  • Title: Interaction between Candida agglutinins and antifungal agents.
    Author: Lutz JC, Nugent KM.
    Journal: Mycopathologia; 1987 Jul; 99(1):21-4. PubMed ID: 3306393.
    Abstract:
    Antifungal agents alter the function and morphology of Candida cell membranes and cell walls. We observed that brief (30 minute) exposure to either amphotericin B or clotrimazole inhibited the agglutination of Candida blastoconidia by murine bronchoalveolar lavage fluid. This inhibition required continuous drug presence. Neither amphotericin nor clotrimazole inhibited Candida agglutination by concanavalin A or pooled human serum. These results demonstrate that antifungal drugs can produce rapid changes in the surface characteristics of some fungi.
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