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  • Title: [Values of MCV,MCH,ROFT and HbA2 for Screening α-Thalassemia in Guangdong Area].
    Author: Liu Y, Lin XY, Huang Y, Huang QW, Chen HL, Shen MN, Ruan JY, Li XY, Xu LH, Fang JP.
    Journal: Zhongguo Shi Yan Xue Ye Xue Za Zhi; 2020 Oct; 28(5):1679-1682. PubMed ID: 33067973.
    Abstract:
    OBJECTIVE: To investigate the values of mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), red cell osmotic fragility test(ROFT) and hemoglobin A2(HbA2) in screening of α-thalassemia in Guangdong area. METHODS: A total of 285 peripheral blood samples in patients treated in our hospital from January 2017 to December 2017 were collected. The detection of thalassemia gene was used as the gold standard, while blood routine examination, hemoglobin electrophoresis, and red cell osmotic fragility test were simultaneously performed. The optimal cut-off values in MCV, MCH, ROFT and HbA2 in α-thalassemia were determined by receiver operator characteristic curve (ROC curve). RESULTS: The most common types of α-thalassemia gene was --SEA/αα (54.59%). Compared with the control group, the differences in MCV, MCH, ROFT and HbA2 showed statistically significantce between different types of α-thalassemia (P<0.05). The best cut-off values of MCV, MCH, ROFT, and HbA2 in the diagnosis of α-thalassemia were 81.45 fl, 27.35 pg, 79.95%, and 2.55% respectively. CONCLUSION: For different laboratories, the cut-off values need to be established for screening α-thalassemia suitable in their own local region．The values of MCV, MCH, ROFT and HbA2 shows higher accuracy and sensitivity in the diagnosis of α-thalassemia. It is recommended to use MCV<81.45fl, MCH<27.35 pg, ROFT<79.95% and HbA2<2.55% as the standards for screening α-thalassemia in Guangdong area. 题目: MCV、MCH、RBC脆性和HbA2在广东地区α-地中海贫血筛查中的价值. 目的: 探讨平均红细胞体积（MCV）、平均血红蛋白量（MCH）、红细胞渗透脆性试验（ROFT）和血红蛋白A2(HbA2)在广东地区筛查α-地中海贫血中的价值. 方法: 收集2017年1月到2017年12月于本院就诊患者外周血285例。以地中海贫血基因检测为金标准，同时进行血细胞常规分析，血红蛋白电泳测定和红细胞渗透脆性试验测定。通过受试者工作曲线(ROC曲线)确定MCV、MCH、ROFT和HbA2在α-地中海贫血中的最佳截断值. 结果: α-地中海贫血基因类型以--SEA/αα最常见（54.59%）。与正常对照组相比，不同分型α-地中海贫血MCV、MCH、ROFT和HbA2的差异均有统计学意义（P<0.05）。MCV、MCH、ROFT和HbA2诊断α-地中海贫血的最佳截断值分别为81.45 fl、27.35 pg、79.95%和2.55. 结论: 不同实验室应该建立适合本地区的α-地中海贫血初筛截断值。MCV、MCH、ROFT和HbA2对于诊断α-地中海贫血具有较高的准确性和灵敏度，广东地区建议使用MCV<81.45 fl、MCH<27.35 pg、ROFT<79.95%和HbA2<2.55%作为筛查α-地中海贫血的标准.
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