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  • Title: Moxalactam versus clindamycin plus tobramycin for the treatment of puerperal infections.
    Author: Pastorek JG, Faro S, Aldridge KE, Nicaud SK.
    Journal: South Med J; 1987 Sep; 80(9):1116-9. PubMed ID: 3306943.
    Abstract:
    Sixty women with the diagnosis of puerperal endometritis were randomized to receive either moxalactam (n = 29) or the combination of clindamycin and tobramycin (n = 31) as therapy for their infection. Endometrial bacteriology consisted of mixed flora, both aerobic and anaerobic gram-positive and gram-negative organisms. Clinical cure was achieved in 27 (93%) of the moxalactam-treated patients and 28 (90%) of those given combination therapy. The two failures of moxalactam therapy were associated with enterococcal infection. Failures of clindamycin/tobramycin therapy were due to enterococcal infection, abscess formation, and moderately severe diarrhea. This study indicates that moxalactam is as effective and safe as the combination of clindamycin/tobramycin for the treatment of postpartum endometritis.
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