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  • Title: Computer-assisted karyotyping with human interaction.
    Author: Oosterlinck A, Van Daele J, De Boer J, Dom F, Reynaerts A, Van Den Berghe H.
    Journal: J Histochem Cytochem; 1977 Jul; 25(7):754-62. PubMed ID: 330726.
    Abstract:
    A system for machine assisted karyotyping and chromosome analysis has been developed. The system uses a drum- or TV-scanner as input device, runs provisionally in 32 K memory, and also allows human interaction on several stages. The accuracy with which banded chromosomes are karyotyped depends strongly on the type of classifier and varies from 40 up to 80%. The accuracy of the human assisted classifier (98%) comes close to that of a skilled technician (99.5%) using manual chromosomal analysis. Due to technical and memory limitations, the time necessary for the karyotyping of one cell is too long and depends on the interaction time; however karyotyping within 5 min, including human interaction, will be possible in the near future.
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