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  • Title: [Isolation and analysis of human leukocyte interferons synthesized by bacterial producer strains].
    Author: Kostrov SV, Borukhov SI, Eremashvili MR, Novikov AA, Skvortsova MA.
    Journal: Antibiot Med Biotekhnol; 1987 Apr; 32(4):243-7. PubMed ID: 3307604.
    Abstract:
    Rapid and sensitive methods for immunochemical estimation of bacterially-made human leukocytic interferons were developed. A large number of strains producing such interferons was analyzed with these methods and optimal ones capable of synthesizing up to 10(10), 10(8), 10(9) and 10(9) IU/l of interferons alpha A, alpha N, alpha F and alpha I1 respectively were selected. The proteins were isolated in homogenous state and their main physico-chemical parameters were characterized. Interferon oligomers were detected. Their formation was partially due to intermolecular disulphide exchange. The effect on interferon alpha A of retinal (vitamin A) and its derivatives efficiently interacting with this protein was studied.
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