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  • Title: A dual-response fluorescent probe for detection and bioimaging of hydrazine and cyanide with different fluorescence signals.
    Author: Mu S, Gao H, Li C, Li S, Wang Y, Zhang Y, Ma C, Zhang H, Liu X.
    Journal: Talanta; 2021 Jan 01; 221():121606. PubMed ID: 33076136.
    Abstract:
    Due to favourable efficiency and low cost, dual-response fluorescent probes play critical roles in the development of fluorescence assay system. Herein, a novel dual-response fluorescent probe (RDCN) was designed and synthesized for the detection of two environmental contaminants: hydrazine (N2H4) and cyanide (CN-). Probe RDCN exhibited discriminative sensing behaviors to N2H4 and CN- with different reaction mechanisms, allowing the high selectivity and sensitivity detection for N2H4 and CN-. The probe itself displayed red-emitting fluorescence as a result of strong intramolecular charge transfer (ICT) between diethylamino and dicyano. After mixing with hydrazine, a new corresponding hydrazone came into being with an intense yellow fluorescence. While, the probe could also largely switch to blue fluorescence in response to CN-. Furthermore, the probe RDCN was successfully employed to determine N2H4 and CN- in water samples with the detection limits of 0.08 μM and 0.33 μM, and to visualize N2H4 and CN- in live cells by means of different fluorescence channels (blue and yellow channels), revealing that probe RDCN has potential applications for discriminative detection N2H4 and CN- in biological environment.
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