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  • Title: The actions of arginine and glucose on glucagon secretion are mediated by opposite effects on cytoplasmic Ca2+.
    Author: Johansson H, Gylfe E, Hellman B.
    Journal: Biochem Biophys Res Commun; 1987 Aug 31; 147(1):309-14. PubMed ID: 3307774.
    Abstract:
    Cytoplasmic Ca2+ (Ca2+i) was monitored in single guinea-pig pancreatic alpha 2-cells exposed to modulators of glucagon release. The stimulatory amino acid arginine raised Ca2+i from 62 to 160 nM, whereas the inhibitor glucose reduced both the latter concentration and basal Ca2+i by 30%. Epinephrine which potentiates arginine-stimulated secretion by increasing cAMP, does so without affecting Ca2+i. The results indicate that glucagon secretion is positively modulated by Ca2+i. It is suggested that glucose-induced lowering of Ca2+i is a fundamental effect in cells where the sugar is readily metabolized.
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