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  • Title: [The expression and significance of interleukin-35 receptor in oral lichen planus].
    Author: Zhang LY, Wang R, Liu T, Cai Y.
    Journal: Hua Xi Kou Qiang Yi Xue Za Zhi; 2020 Oct 01; 38(5):513-518. PubMed ID: 33085234.
    Abstract:
    OBJECTIVE: To investigate the expression of glycoprotein 130 (gp130) and interleukin 12 receptor β2 (IL-12Rβ2) in two subunits of interleukin-35 receptor (IL-35R), singal transducer and activator of transcription (STAT) 1 and STAT4 in oral lichen planus (OLP) tissues, and to explore the role and significance of IL-35R in the formation and development of OLP lesions. METHODS: Totally 41 samples of OLP tissues (OLP group) and 15 samples of normal oral mucosa (control group) were collected. The expression levels of gp130, IL-12Rβ2, STAT1, STAT4 mRNA in the tissues were detected by real-time fluorescent quantitative polymerase chain reaction and the distribution and expression of protein gp130 and IL-12Rβ2 were detected by immunohistochemistry. The potential relationship between gp130 and IL-12Rβ2 and clinical features of OLP was analyzed. RESULTS: 1) The expression levels of gp130, IL-12Rβ2, STAT1 and STAT4 mRNA in the OLP group were significantly higher than those in the control group (P<0.05). 2) The positive expression rates of gp130 and IL-12Rβ2 protein in the OLP group were higher than those in the control group (P<0.05). The expression of gp130 and IL-12Rβ2 proteins in OLP tissues were positively correlated (r=0.984, P<0.001). 3) The expression rates of gp130 and IL-12Rβ2 protein in erosive OLP tissues were significantly higher than those in non-erosive ones (P<0.05). CONCLUSIONS: The expression of IL-35R and STAT is up-regulated in OLP tissues, and the expression of IL-35R is related to the clinical classification of OLP, suggesting that IL-35R might play an important role in the formation and development of damage OLP lesions. 目的 通过检测白细胞介素35受体（IL-35R）两亚基糖蛋白130（gp130）、白细胞介素12受体β2（IL-12Rβ2）及信号转导和转录激活因子（STAT）1、STAT4在口腔扁平苔藓（OLP）组织中的表达，探讨IL-35R在OLP病损形成和发展中的作用及意义。方法 收集41例OLP组织（OLP组）和15例正常口腔黏膜组织（对照组）为研究对象。采用实时荧光定量聚合酶链反应检测组织中gp130、IL-12Rβ2、STAT1、STAT4 mRNA的表达水平，免疫组织化学（IHC）检测组织中gp130、IL-12Rβ2蛋白的表达及分布，并分析gp130、IL-12Rβ2蛋白表达与OLP临床特征的关系。结果 1）OLP组gp130、IL-12Rβ2、STAT1、STAT4 mRNA的相对表达量均高于对照组（P<0.05）。2）OLP组gp130、IL-12Rβ2蛋白的阳性表达率均高于对照组（P<0.05），且gp130、IL-12Rβ2蛋白在OLP组织中的表达呈正相关（r=0.984，P<0.001）。3）糜烂型OLP组织gp130、IL-12Rβ2蛋白的阳性表达率高于非糜烂型（P<0.05）。结论 IL-35R及STAT在OLP组织中表达上调，且IL-35R的表达与OLP的临床分型有关，提示IL-35R可能在OLP病损形成及发展中起重要作用。.
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