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  • Title: Mysterious and fascinating: DNA polymerase ɩ remains enigmatic 20 years after its discovery.
    Author: Vaisman A, Woodgate R.
    Journal: DNA Repair (Amst); 2020 Sep; 93():102914. PubMed ID: 33087280.
    Abstract:
    With the publication of the first paper describing the biochemical properties of DNA polymerase iota (polɩ), the question immediately arose as to why cells harbor such a low-fidelity enzyme which often violates the Watson-Crick base pairing rules? Yet 20 years after its discovery, the cellular function of polɩ remains unknown. Here, we provide a graphical review of the unique biochemical properties of polɩ and speculate about the cellular pathways in which enigmatic polɩ may participate.
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