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  • Title: Bromocriptine-desipramine protocol in treatment of cocaine addiction.
    Author: Giannini AJ, Billett W.
    Journal: J Clin Pharmacol; 1987 Aug; 27(8):549-54. PubMed ID: 3308977.
    Abstract:
    Thirty-six male cocaine abusers, in withdrawal, were studied for 99 days in a double-blind design. Treatment with bromocriptine was significantly more effective than placebo in alleviating withdrawal symptoms. Adding desipramine to the bromocriptine regimen was significantly more effective than either placebo or bromocriptine alone. The authors hypothesize that these results support a model of dopamine depletion and receptor supersensitivity in cocaine withdrawal.
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