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  • Title: [Effects of insulin in vitro in the fatty tissue of rats with alloxan diabetes after insulin treatment or administration of insulin-like growth factors from human serum].
    Author: Kosovskiĭ MI, Turakulov IaKh, Mirakhmedov MM, Katkova SP.
    Journal: Probl Endokrinol (Mosk); 1987; 33(3):46-9. PubMed ID: 3309932.
    Abstract:
    Insulin insufficiency in rats caused by alloxan, results in a decrease in the sensitivity of the fatty tissue to insulin determined by glucose oxidation and synthesis of lipids manifested in a decrease in a maximum response of the tissue to insulin. Multiple injection of insulin as well as of partially purified total fraction of insulinoid growth factors causes an increase in a maximum response of the fatty tissue to insulin and a right-hand shift of dose-response curves. The total effect of the injection of insulin or partially purified growth factors is expressed in elevated sensitivity of the fatty tissue to insulin.
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