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Title: [Comparison of the safety and outcomes between keyhole surgery and total laminectomy for resection of intradural extramedullary spinal cord tumors].
Author: Li Y, Xu J, Zheng W.
Journal: Zhonghua Yi Xue Za Zhi; 2020 Oct 27; 100(39):3093-3098. PubMed ID: 33105961.
Abstract:
Objective: To compare the safety and outcomes between keyhole surgery and total laminectomy for resection of intradural extramedullary spinal cord tumors. Methods: Retrospectively collected the clinical data of 102 patients with intradural extramedullary spinal cord tumors(≤3 cm) treated by surgery in Department of Orthopedics in Fujian Provincial Hospital from January 2014 to January 2017. Fifty cases underwent the keyhole surgery and the other 52 received total laminectomy. The operation time, volume of intraoperative bleeding, the leaving bed time, the length of postoperative hospital stay, drainage, postoperative complications, intraoperative neuroelectrophysiological monitoring (IONM), preoperative and postoperative visual analogue score (VAS), neck disability index (NDI), Oswestry disability index (ODI), McCormick spinal cord function grading were analyzed and compared between the two groups to evaluate the safety and clinical outcomes. The data of two groups were compared by t, χ(2) or rank sum test. Results: The keyhole group was followed up for (30±15) months and the total laminectomy group was followed up for (45±15) months. All the tumors were completely resected. All the incision healed well and no cerebrospinal fluid leakage occurred. There was no statistically significant differences in baseline data, operation time, the results of IONM, preoperative and 3 months, 6 months, 12 months postoperative VAS, NDI (cervical tumors), ODI (thoracic and lumbar tumors), McCormick spinal cord function grading, tumor recurrence between the two groups (all P>0.05). The keyhole group had less intraoperative bleeding than that in the total laminectomy group ((73±24) ml vs (136±26) ml, t=-12.610, P<0.05), earlier postoperative leaving bed time ((1.4±0.6) d vs (6.5±1.0) d, t=-31.822, P<0.05), and the postoperative hospital stay was shorter ((4.3±0.8) d vs (11.2±2.0) d, t=-22.319, P<0.05), and it was more advantageous in terms of drainage. The VAS, NDI and ODI in the keyhole group improved significantly compared with those in the total laminectomy group 2 weeks post operation (all P<0.05). Conclusion: Compared with the total laminectomy, keyhole surgery is suitable for the treatment of intradural extramedullary spinal cord tumors with small size and limited location, and it is equivalently safe with faster functional recovery. 目的： 比较keyhole手术与全椎板手术切除髓外硬膜下肿瘤的安全性和疗效。 方法： 回顾性收集福建省立医院骨二科2014年1月至2017年1月手术治疗的102例髓外硬膜下肿瘤（≤3 cm）患者临床资料，50例行keyhole手术，52例行全椎板手术。分析两组病例的手术时间、出血量、术后下床时间、术后住院时间、引流情况、术后并发症、术中神经电生理监测结果（IONM）、术前及术后疼痛视觉模拟评分（VAS）、颈椎功能障碍指数（NDI）、Oswestry功能障碍指数（ODI）、McCormick脊髓功能分级，评估两组安全性和疗效。 结果： keyhole组随访（30±15）个月，全椎板组随访（45±15）个月。两组肿瘤均完全切除，未发生切口感染、脑脊液漏等并发症。两组病例在基线资料、手术时间、IONM、术前和术后3、6、12个月VAS、NDI（颈段肿瘤）、ODI（胸腰段肿瘤）、McCormick脊髓功能分级、肿瘤复发方面差异均无统计学意义（均P>0.05）。keyhole组较全椎板组出血量更少[（73±24）ml比（136±26）ml，t=-12.610，P<0.05]，术后下床时间更早[（1.4±0.6）d比（6.5±1.0）d，t=-31.822，P<0.05]，术后住院时间更短[（4.3±0.8）d比（11.2±2.0）d，t=-22.319，P<0.05]，且在置管引流方面更具优势。keyhole组术后2周VAS、NDI、ODI较全椎板组改善明显（均P<0.05）。 结论： 与全椎板手术相比，keyhole手术适用于体积较小、部位较局限的肿瘤治疗，而安全性与之相当，术后恢复快，近期临床疗效确切，远期疗效两者相近。.

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