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  • Title: Antibodies to Pf155, a major antigen of Plasmodium falciparum: seroepidemiological studies in Haiti.
    Author: Deloron P, Duverseau YT, Zevallos-Ipenza A, Magloire R, Stanfill PS, Nguyen-Dinh P.
    Journal: Bull World Health Organ; 1987; 65(3):339-44. PubMed ID: 3311436.
    Abstract:
    The presence of malaria parasites and the serological antibody responses against whole Plasmodium falciparum and the Pf155 antigen were studied in the population of a small rural locality in Haiti in December 1985. Only 7 (1.5%) of the individuals were found to be infected with P. falciparum, the only species observed. Antibodies to P. falciparum were detected in an ELISA in 38.2% of the sera, the positivity rates being age-related. Anti-Pf155 antibodies were detected in 12.5% and 13.6% of individuals by two different techniques used. The anti-Pf155 positivity rates increased only after 25 years of age. No trends were detected for a clear-cut protective value of Pf155 antibodies against clinical malaria and further longitudinally conducted field surveys are needed to satisfactorily assess the potential protective effect of Pf155 antibodies.
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