These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: T-lymphocyte and experimental autoimmune uveoretinitis.
    Author: Mochizuki M.
    Journal: Jpn J Ophthalmol; 1987; 31(2):230-4. PubMed ID: 3312733.
    Abstract:
    The immunopathogenic mechanisms underlying S-antigen-induced experimental autoimmune uveoretinitis (EAU) were discussed with particular emphasis on the cellular immune response on the basis of the following data: 1) athymic nude rats did not develop EAU unless sensitized lymphocytes obtained from heterozygous rats were transferred into the nude rats; 2) cyclosporine, an immunosuppressant selective to the T-lymphocytes, completely inhibited the cellular immune response to S-antigen as well as EAU induction; 3) a lymphocyte population having the capacity to produce interleukin 2 in response to S-antigen appeared prior to the onset of EAU; and 4) EAU was successfully transferred into syngenic animals by sensitized T-lymphocytes or by a T-cell line specific to S-antigen. These data were thought to indicate that the T-lymphocyte or the cellular immune response to S-antigen constitutes the essential factor for the development of EAU.
    [Abstract] [Full Text] [Related] [New Search]