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  • Title: Deconjugation of bile acids by human intestinal bacteria implanted in germ-free rats.
    Author: Chikai T, Nakao H, Uchida K.
    Journal: Lipids; 1987 Sep; 22(9):669-71. PubMed ID: 3312906.
    Abstract:
    Fecal bile acids in germ-free rats were analyzed after inoculation with Bacteroides vulgatus, Bifidobacterium longum, Escherichia coli or Clostridium ramosum. B. vulgatus preferentially deconjugated tauro-beta-muricholic acid and B. longum taurocholic acid. C. ramosum deconjugated both bile acids, but E. coli deconjugated neither. 7 alpha-Dehydroxylation of bile acids was negligible even after 18 days of inoculation, but a small amount of 7-oxo-bile acids, less than 5%, was formed. Fecal excretion of bile acids increased after inoculation with B. vulgatus, B. longum and C. ramosum, but not with E. coli.
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