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  • Title: [6 beta-hydroxycortisol: a non-invasive reflection of enzymes of drug metabolism].
    Author: Zhiri A, Wellman-Bednawska M, Siest G.
    Journal: Pathol Biol (Paris); 1987 Sep; 35(7):1087-93. PubMed ID: 3313218.
    Abstract:
    6-beta-hydroxycortisol (6-beta-OHF) is the main unconjugated metabolite of cortisol in human urine. 6-beta-OHF could be assayed in urine by several methods : chromatography followed by colour reaction, high performance liquid chromatography, radioimmunoassay and enzyme immunoassay. Urinary 6-beta-OHF is increased in some physiological conditions (such as pregnancy) and pathological states (such as hypercortisolemia and liver disease). The measurement of 6-beta-OHF in human urine may provide a useful index of enzyme induction, its excretion being enhanced by many inducers of the mixed function oxygenase.
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