These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Iridium-Catalyzed Enantioselective Unbiased Methylene C(sp3 )-H Borylation of Acyclic Amides.
    Author: Yang Y, Chen L, Xu S.
    Journal: Angew Chem Int Ed Engl; 2021 Feb 15; 60(7):3524-3528. PubMed ID: 33145910.
    Abstract:
    We herein report amide directed enantioselective β-C(sp3 )-H borylation of unbiased methylene C-H bonds of acyclic amides enabled by iridium catalysis for the first time. The key to the success of this transformation relies on the careful selection of the combination of iridium precursor and chiral bidentate boryl ligands. A variety of functional groups are well-tolerated, affording chiral β-functionalized amides in good to excellent enantioselectivities. We also demonstrate the application of the current method by stereospecific conversion of C-B bond into other functionalities.
    [Abstract] [Full Text] [Related] [New Search]