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  • Title: Improved exercise performance of hypertensive patients treated with guanfacine (Estulic Sandoz).
    Author: Bazika V.
    Journal: Cor Vasa; 1987; 29(4 Suppl 1):42-5. PubMed ID: 3315450.
    Abstract:
    Guanfacine (trade name Estulic Sandoz), has turned out to be a very effective antihypertensive drug. During follow-up of 20 men with a hypertensive response to exercise, and with blood pressure values reaching or exceeding 230/120 mmHg, administration of 1-2 mg of the drug daily led to a decrease in heart rate and blood pressure. At the same time, patients' performance during exercise increased considerably, from 705 W prior to guanfacine administration, to 1.128 W after three-week therapy. Of the biochemical parameters monitored, a statistically significant decrease was observed in the levels of cholesterol, triglycerides and non-esterified fatty acids. There was an insignificant decrease in glycaemia.
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