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  • Title: Action of chlorhexidine on budding Candida albicans: scanning and transmission electron microscopic study.
    Author: Bobichon H, Bouchet P.
    Journal: Mycopathologia; 1987 Oct; 100(1):27-35. PubMed ID: 3317060.
    Abstract:
    Chlorhexidine is widely used as a bacterial drug whose method of action has been well described in bacteria. Its fungicidal properties have been proved. We show here the effects of a sublethal dose of a preparation of digluconate of chlorhexidine on budding Candida albicans. A fungistatic action is revealed by a decrease in the percentage of budding cells, and two main types of alterations can be observed with transmission electron microscopy (T.E.M.): a loss of cytoplasmic components and a coagulation of nucleoproteins. With scanning electron microscopy (S.E.M.), the cell walls show morphological modifications.
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