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  • Title: Chicken II luteinizing hormone-releasing hormone inhibits the M-current of bullfrog sympathetic neurons.
    Author: Jones SW.
    Journal: Neurosci Lett; 1987 Sep 23; 80(2):180-4. PubMed ID: 3317136.
    Abstract:
    The M-current of dissociated bullfrog sympathetic neurons, measured by the whole-cell patch clamp technique, is powerfully inhibited by chicken II LH-RH (luteinizing hormone-releasing hormone), with 50% inhibition near 1 nM. Chicken II LH-RH is approximately 100 times more potent than salmon LH-RH, and at least 1000 times more potent than other known naturally occurring LH-RH analogs (chicken I LH-RH, mammalian LH-RH, and lamprey LH-RH). This high potency makes chicken II LH-RH a candidate for the endogenous transmitter mediating the late, slow excitatory postsynaptic potential (EPSP) in bullfrog sympathetic ganglia.
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