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  • Title: Squamous carcinoma ex pleomorphic adenoma of the lacrimal gland.
    Author: Malick H, Kumari R, Lokovitis V, Mudhar HS, Vaidhyanath R, Sampath R.
    Journal: Orbit; 2022 Apr; 41(2):260-263. PubMed ID: 33172316.
    Abstract:
    We present a very rare case of squamous cell carcinoma (SCC) ex pleomorphic adenoma of the lacrimal gland. Our patient presented with a 12 month history of painful proptosis of his left eye associated with severe headache. Imaging showed a left lacrimal gland lesion with extensive orbital disease extending into lateral and superior rectus muscles, cavernous sinus and the greater wing of the sphenoid. A lacrimal gland biopsy showed a combination of small bland glandular structures and sclerotic, elastin-containing stroma showing that the SCC had arisen on a background of a probable pleomorphic adenoma. Treatment with cisplatin and 5-Fluorouracil proved efficacious with a significant reduction of orbital and post-orbital disease on interval scanning.
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