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  • Title: Active immunization against hepatitis B: immunogenicity of a recombinant DNA vaccine in females, heterosexual and homosexual males.
    Author: Laukamm-Josten U, von Laer G, Feldmeier H, Bienzle U, Uy A, Thomssen R, Guggenmoos-Holzmann I.
    Journal: Postgrad Med J; 1987; 63 Suppl 2():143-6. PubMed ID: 3317351.
    Abstract:
    Three groups of subjects (58 females, 54 heterosexual males, and 50 homosexual males) received three doses of a recombinant DNA yeast-derived hepatitis B vaccine according to a 0, 1, and 6 month vaccination schedule. Local and general side effects were mild. Seroconversion rates after three injections were not significantly different between the groups. Females showed a significantly higher anti-HBs response than both groups of males, and heterosexual males had higher antibody titres than homosexual males. Among the four homosexual non-responders, three were carriers of the human immunodeficiency virus.
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