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  • Title: Vaccination of newborns of HBsAg-positive carrier mothers with a recombinant DNA hepatitis B vaccine.
    Author: Cadranel S, Zeghlache S, Fernandez S, Safary A, André F.
    Journal: Postgrad Med J; 1987; 63 Suppl 2(736):159-60. PubMed ID: 3317355.
    Abstract:
    Thirty neonates born to HBsAg-positive mothers were vaccinated with a 20 microgram dose of the SmithKline Biologicals recombinant DNA yeast-derived vaccine within 24 hours after birth, with similar inoculations repeated 1 and 2 months later. Preliminary results indicate that the recombinant vaccine was well tolerated and immunogenic. A 100% seroconversion rate was achieved 4 months after the first vaccine dose and the anti-HBs geometric mean titres progressively rose from 14 to 31,279 and 361 IU/l at months 1, 2, 4, and 6, respectively. Although a longer period of observation and comparison with a historical control group are needed to evaluate its protective efficacy in this high-risk population, the fact that no vaccinated newborns have been infected is encouraging.
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