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  • Title: Bone single-photon emission computed tomography-CT peak standardized uptake value for chronic osteomyelitis, osteoradionecrosis and medication-related osteonecrosis of the jaw.
    Author: Minami Y, Ogura I.
    Journal: J Med Imaging Radiat Oncol; 2021 Apr; 65(2):160-165. PubMed ID: 33180378.
    Abstract:
    INTRODUCTION: Recently, standardized uptake value (SUV) has been applied for the evaluation of SPECT-CT. This study was performed to investigate the bone SPECT-CT peak SUV for chronic osteomyelitis, osteoradionecrosis and medication-related osteonecrosis of the jaw (MRONJ). METHODS: Sixty-five patients with jaw lesions (12 chronic osteomyelitis, 12 osteoradionecrosis and 41 MRONJ) underwent SPECT-CT after injection of technetium-99m hydroxymethylene diphosphonate. The peak SUV was compared for the chronic osteomyelitis with osteoradionecrosis and MRONJ using GI-BONE software. Statistical analyses for the peak SUV were performed by one-way repeated measures analysis of variance with Tukey's HSD test. A P-value lower than 0.05 was considered as statistically significant. RESULTS: Peak SUV for chronic osteomyelitis (15.6 ± 4.4) was significantly higher than those for osteoradionecrosis (6.7 ± 2.1, P = 0.000) and MRONJ (10.7 ± 6.1, P = 0.019). CONCLUSION: The SPECT-CT peak SUV using GI-BONE software can be useful for the evaluation of jaw lesions, such as chronic osteomyelitis, osteoradionecrosis and MRONJ.
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