These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Molecularly Imprinted Polymer Based GCE for Ultra-sensitive Voltammetric and Potentiometric Bio Sensing of Topiramate.
    Author: Khalifa ME, Ali TA, Abdallah AB.
    Journal: Anal Sci; 2021 Jul 10; 37(7):955-962. PubMed ID: 33191368.
    Abstract:
    Topiramate (TOP) drug is classified as one of the most commonly used human drugs for anticonvulsants and antiepileptic, so its rapid detection and monitoring is of great importance. In this work, new potentiometric (MIP/PVC/GCE) and voltammetric (MIP/GO/GCE) sensors for the selective and sensitive determination of TOP were fabricated based on the molecularly imprinted polymer (MIP) approach. The MIP was synthesized by the polymerization of acrylamide and methacrylic acid as monomers, in the presence of TOP as a template and ethylene glycol dimethacrylate as a cross-linker. The obtained products were characterized by FT-IR, SEM, BET, and EDX. The MIP was embedded in a plasticized polyvinyl chloride membrane and used as a potentiometric sensor for sensing TOP. Alternatively, the synthesized MIP and graphene oxide (GO) were deposited layer-by-layer on the surface of GCE to construct a voltammetric sensor for studying the electrochemical behavior of the drug. Under optimized conditions, both electrochemical sensors showed excellent linear relationships between the concentration of TOP and the response signals of MIP/GO/GCE or MIP/PVC/GCE sensors in the 2.7 × 10-10 to 4.9 × 10-3 M and 1 × 10-9 to 3.4 × 10-3 M ranges, respectively. Also, both sensors have good reproducibility and high stability for up to 15 days for a voltammetric sensor and 28 days for a potentiometric sensor. The utility of these sensors was checked for TOP analysis in different real samples with good recovery (92.8 - 99%).
    [Abstract] [Full Text] [Related] [New Search]