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  • Title: CALLA-negative, TdT- and CD7-positive acute lymphoblastic leukemia: a phenotype associated with poor prognosis.
    Author: De Rossi G, Aloe Spiriti MA, Cafolla A, Gastaldi R, Lo Coco F, Lopez M, Luciani M, Pasqualetti D, Testi AM, Mandelli F.
    Journal: Diagn Clin Immunol; 1987; 5(3):140-3. PubMed ID: 3319281.
    Abstract:
    Eight ALL patients displaying a CD7+, Tdt+, CD10-, T MoAbs-, myeloid MoAbs-, AP+ phenotype are described. Some patients showed well-known risk factors such as cytogenetic abnormalities, high WBC count, mediastinal mass, and/or organomegalies. The clinical behaviour was very poor and only one patient is in CR and off therapy. Therefore such a pre-T phenotype, although sometimes associated with the other risk factors, could be considered a poor prognosis phenotype.
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