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  • Title: Regional chromosomal assignment of human renin gene to 1q12----qter and use in linkage studies in Charcot-Marie-Tooth disease.
    Author: Griffiths LR, Nicholson GA, Ross DA, Zwi MB, McLeod JG, Mohandas T, Morris BJ.
    Journal: Cytogenet Cell Genet; 1987; 45(3-4):231-3. PubMed ID: 3319438.
    Abstract:
    The gene for renin, previously mapped to human chromosome 1, was further localized to 1q12----qter using human-mouse somatic cell hybrid DNAs. The renin DNA probe used (lambda HR5) could detect a HindIII restriction fragment length polymorphism. When used in studies of 12 informative families, no linkage could be found between the renin gene and Charcot-Marie-Tooth disease. Furthermore, an association of any renin allele with hypertension was not apparent.
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