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  • Title: Phencyclidine analogues inhibit NMDA-stimulated [3H]GABA release from cultured cortex neurons.
    Author: Drejer J, Honoré T.
    Journal: Eur J Pharmacol; 1987 Nov 10; 143(2):287-90. PubMed ID: 3319651.
    Abstract:
    The inhibition of [3H]TCP binding to rat cortical membranes by substances of the PCP/sigma-opiate type was compared with effects of the same compounds on N-methyl-D-aspartate (NMDA) responses in cultured mouse cortex neurons. A new technique of excitatory amino acid-induced [3H]GABA (gamma-amino-butyric acid) release in a continuous superfusion model was used for the purpose. A similar rank order of potencies was found for the substances whether as inhibitors of [3H]TCP binding (MK 801 greater than PCP greater than ketamine-cyclazocine) or as antagonists of NMDA (20 microM)-stimulated [3H]GABA release in the cultured neurons (phencyclidine = MK 801 greater than ketamine greater than cyclazocine).
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