These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Metallocene QACs: The Incorporation of Ferrocene Moieties into monoQAC and bisQAC Structures.
    Author: Sommers KJ, Bentley BS, Carden RG, Post SJ, Allen RA, Kontos RC, Black JW, Wuest WM, Minbiole KPC.
    Journal: ChemMedChem; 2021 Feb 04; 16(3):467-471. PubMed ID: 33197298.
    Abstract:
    Inspired by the incorporation of metallocene functionalities into a variety of bioactive structures, particularly antimicrobial peptides, we endeavored to broaden the structural variety of quaternary ammonium compounds (QACs) by the incorporation of the ferrocene moiety. Accordingly, 23 ferrocene-containing mono- and bisQACs were prepared in high yields and tested for activity against a variety of bacteria, including Gram-negative strains and a panel of clinically isolated MRSA strains. Ferrocene QACs were shown to be effective antiseptics with some displaying single-digit micromolar activity against all bacteria tested, demonstrating yet another step in the expansion of structural variety of antiseptic QACs.
    [Abstract] [Full Text] [Related] [New Search]