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  • Title: Epidemiological studies of neural tube defects in Newfoundland.
    Author: Frecker M, Fraser FC.
    Journal: Teratology; 1987 Dec; 36(3):355-61. PubMed ID: 3321520.
    Abstract:
    A 9-year survey of neural tube defects in Newfoundland showed (1) evidence for secular variation, with a peak in 1980, but no general downward trend as seen in some other populations; (2) significant geographic variation which did not correlate with hardness or nitrate content of the lake water; (3) a tendency for the proportion of females among anencephalic births to increase with increasing frequency of anencephaly among geographic regions. This supports previous evidence for a female-specific contribution to the causes of increased liability to neural tube defect.
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