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  • Title: Decreased insulin binding and antilipolytic response in adipocytes from patients with Cushing's syndrome.
    Author: Calle C, Carranza MC, Simón MA, Torres A, Mayor P.
    Journal: Biosci Rep; 1987 Sep; 7(9):713-9. PubMed ID: 3322423.
    Abstract:
    Human adipocytes from patients with chronic endogenous hypercortisolism (Cushing's syndrome) showed a statistically significant decrease in insulin binding at low unlabelled-insulin concentrations but no change in receptor numbers (Cushing's 180,000 +/- 48,000 (3) receptors/cell and controls 189,000 +/- 30,000 (7)) together with a fourfold decrease in apparent receptor affinity (ED50: Cushing's 2.25 x 10(-9) M and controls 0.57 x 10(-9) M) and a decreased sensitivity to the antilipolytic effect of insulin. These events could represent the final situation of a chronic and endogenous regulation by high levels of cortisol of insulin receptors in human adipose tissue.
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