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  • Title: Influence of enterally administered ornithine alpha-ketoglutarate on hormonal patterns in burn patients.
    Author: Vaubourdolle M, Cynober L, Lioret N, Coudray-Lucas C, Aussel C, Saizy R, Giboudeau J.
    Journal: Burns Incl Therm Inj; 1987 Oct; 13(5):349-56. PubMed ID: 3322511.
    Abstract:
    Plasma concentrations of glucose, insulin, C-peptide, glucagon, cortisol and hGH were measured in burn patients (mean burn surface area 21 per cent) treated or not with ornithine alpha-ketoglutarate (OKG). An increase in basal values of glucose, insulin, C-peptide and cortisol was demonstrated in both groups, whereas hGH values diminished. OKG modified neither insulin nor hGH values 24 h after its enteral administration nor insulin levels within the first 4 h after intake. On the other hand, 60 min after enteral nutrition was restarted the hyperglycaemia observed in untreated subjects was reduced by OKG whereas a hyperinsulinism was observed in both groups. These results suggest that: (i) the anticatabolic/anabolic action of OKG in burn patients is not mediated by insulin or hGH, (ii) OKG probably induces an increase in glucose tolerance in burn patients, in whom there is a state of insulin resistance. The mechanism of this action requires further study.
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