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  • Title: Obesity and thermogenesis in man.
    Author: Acheson KJ.
    Journal: Diabete Metab; 1987; 13(5):549-53. PubMed ID: 3322893.
    Abstract:
    The treatment of obesity has until recently concentrated upon decreasing energy intake. Experiments using animal models of obesity have demonstrated that a defective thermogenic response to food ingestion is involved in the development of obesity. In man the evidence is less conclusive since there are as many studies which report a decreased thermogenesis in the obese as those which report a similar thermogenic response in obese and lean individuals. Evidence is given supporting the involvement of the sympathetic nervous system in the thermic response to glucose/insulin infusions in both lean and obese individuals and attempts to resolve the controversy as to why some studies report that the obese have a decreased and other studies a similar thermic response to nutrient administration.
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