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  • Title: Enantioselective Bioaccumulation of the Chiral Insecticide Indoxacarb in Zebrafish (Danio rerio).
    Author: Li Y, Liang H, Qiu L.
    Journal: Environ Toxicol Chem; 2021 Apr; 40(4):1007-1016. PubMed ID: 33238038.
    Abstract:
    Indoxacarb is a typical chiral insecticide widely used in agricultural pest control. In the present study, zebrafish was used as a model animal to explore the enantioselective bioaccumulation behavior of indoxacarb to nontarget species in aquatic environments. Zebrafish were exposed to 0.025 and 0.1 mg/L rac-indoxacarb solution for 12 d under the semistatic method, and the bioconcentration factor (BCF) and enantiomeric fraction of zebrafish were investigated. The results showed that the (-)-R-indoxacarb preferentially accumulated in zebrafish. The BCF values at 0.025 mg/L exposure levels were 1079.8 and 83.4 L/kg for (-)-R-indoxacarb and (+)-S-indoxacarb after 12 d, respectively. The BCF values at 0.1 mg/L exposure levels were 1752.1 and 137.0 L/kg for (-)-R-indoxacarb and (+)-S-indoxacarb after 10 d, respectively. The half-life values of (-)-R-indoxacarb and (+)-S-indoxacarb were 3.47 and 2.05 d for 0.025 mg/L concentration exposure and 4.95 and 2.66 d for 0.1 mg/L concentration exposure, respectively. The enantiomeric fraction values were in the range of 0.48 to 0.55 and 0.89 to 1.00 for water and zebrafish samples, respectively. Studies on the enantioselective bioaccumulation behavior of indoxacarb will provide data for assessing the environmental fate and potential toxic effects of indoxacarb on aquatic organisms. Environ Toxicol Chem 2021;40:1007-1016. © 2020 SETAC.
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